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The Male Contraceptive Pill - Statements from our Physicians

Dr. Peter Schlegel James J. Colt Professor and Chairman of Urology, Weill Cornell Medical College Professor of Reproductive Medicine, Urologist-in-Chief, New York Presbyterian Hospital

Recently The Telegraph published on the first clinical trials of the male contraceptive pill.  Statements from our physicians are below:

"The recent study on dimethandrolone/progestin as an oral male contraceptive by Dr. Stephanie Page and associates from the University of Washington and associated medical centers, including UCLA, continues to provide data on the potential development of the "male pill."  The article was published in the journal, Andrology, last year (Andrology 2017 Mar;5(2):278-285) and outlines the effectiveness and lack of side effects.  Acceptance and introduction of "male pills" has been limited in the past because of concerns with whether men will actually take the pills reliably as well as the reversability of effects.  It is likely that the drug would still take many years to be available for potential patients."

- Dr. Peter Schlegel

- Dr. Darius Paduch Associate Professor of Urology, and Reproductive Medicine, Weill Cornell Medical College, Associate Research Director of the Fellowship Program in Male Infertility and Andrology.

"There is no question that there is a need for development in alternatives to condoms and vasectomy, the only approved methods of contraception for men. The work done at UW is another "me too" type of study, and lacks anything innovative. The authors use an oral testosterone preparation to suppress production of FSH and LH, two hormones driving sperm production and natural testosterone productive, respectively. The "hormonal" male contraceptive unfortunately are not as effective as female hormonal contraceptives. Multiple leading institutions and research groups have tried and failed to develope and bring through the approval process male contraceptive variations; hence this is likely not the answer. Our group has focused on using small mRNA to modulate sperm production, nut using hormonal methods. Early research into how small RNA regulates sperm production was funded by the NIH for the last four years, bringing prommising targets for therapy."

- Dr. Darius Paduch

Center for Male Reproductive Medicine & Microsurgery Weill Cornell Medicine
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New York, NY 10065