Pfizer COVID-19 vaccine appointments are available to our patients. Sign up for Connect today to schedule your vaccination. Continue your routine care with us by scheduling an in-person appointment or Video Visit.

Physical Evaluation

Physical examination is performed in a warm room by an examiner with warm-gloved hands, Contraction of the dartos muscle induced by a cold room or cold examining hands makes examination of the scrotum and its contents difficult. A proper fertility examination does not consist of a casual observation of the scrotum and palpation of its contents. Have the patient completely disrobe and stand with his arms outstretched. Observe the general body habitus and hair distribution. Men who are incompletely masculinized have disproportionately long extremities due to absent or deficient androgen stimulation required for epiphyseal closure at the time of puberty. This is seen in men with hypogonadotropic hypogonadism (Kallmann's syndrome when associated with absent sense of smell or other midline defects) or Kleinfelter's syndrome.

After evaluation of body habitus, the thyroid is palpated and the heart and lungs auscultated. Chronic bronchitis associated with congenital epididymal dysplasia is seen in Young's syndrome. Situs inversus with associated immotile sperm is seen in immotile cilia (Kartagener's) syndrome. The breasts are observed and palpated for gynecomastia, which can be associated with estrogen secreting testicular neoplasms, adrenal tumors, and liver disease. Nipple discharge or tenderness may be seen with prolactin-secreting pituitary adenomas. The abdomen is palpated and percussed. A large varicocele that does not collapse in the supine position warrants a search for an abdominal mass. An enlarged liver suggests hepatic dysfunction, which may be associated with infertility due to altered sex steroid metabolism. The penis and urethral meatus is examined for condylomata. The urethra is milked for discharge. The location of the meatus is noted. Severe hypospadias may result in inadequate delivery of semen into the vagina.

Scrotal examination is first performed with the patient supine. This allows a varicocele, if present, to collapse; testis size and consistency can then be properly assessed. Use an orchidometer to measure testicular size. Normal testicular volume ranges from 15 to 30 cm . The testes should be firm in consistency. A change in testicular consistency is indicative of testicular pathology. Small soft testes indicate poor spermatogenesis. Small hard testes suggest postorchitis or posttorsion atrophy or Kleinfelter's syndrome. Focal irregularities in consistency raise the suspicion of malignancy. Smooth firm nodules palpated on the surface of the testis usually represent tunica albuginea cysts. Mobile small hard bodies,corpora amylacea, may be palpated floating within the tunica vaginalis. Transillumination of the scrotum in a darkened room differentiates solid from cystic masses. In general, testes that are normal in size and-consistency usually have normal sperm production, whereas small-volume, soft testes are associated with impaired spermatogenesis. The normal epididymis, posterolateral to the testes, is soft and barely palpable. Induration, modularity, or irregularities are suggestive of epididymal pathology. A full, firm, easily outlined epididymis that is nontender suggests epididymal obstruction. Epididymal cysts or spcruiutoccies are firm, smooth, transilluminate, and almost always located in the caput. The vas deferens should be palpated bilaterally. The vas is the diameter and consistency of a venetian blind cord, and is usually posteromedial and separate from the internal spermatic cord structures. We have observed bilateral congenital absence of the vas deferens (CAV) in 1.3% of of patients presenting for infertility evaluation. With a relaxed scrotum, the diagnosis of CAV can almost always be made by palpation. These men will have azoospermia associated with low seminal volumes and nonclotting clear ejaculate. Serum follicle-stimulating hormone (FSH) is usually normal, reflecting normal spermatogenesis. Testes biopsy and scrotal exploration are not necessary prior to therapy. Because the vas deferens derives from the ureteral bud, CAV is associated with. an 11% incidence of renal agenesis and abnormalities. A renal sonogram should be obtained in all men with CAV. Most men with CAV test positive for cystic fibrosis gene mutations, although they do not have any pulmonary manifestations of this disease.We test the patient and their wives for cystic fibrosis (CFTR) gene mutations and refer the couples for genetic counseling.

Men with cystic fibrosis (CFTR mutations in association with digestive and/or pulmonary problems) will often have bilateral congenital absence of the vas deferens. CAV, whether associated with cystic fibrosis or not, may be treated using sperm retrieval and in vitro fertilization to effect pregnancies.

Large varicoceles are readily seen through the relaxed scrotal skin in a warm room with the patient standing. Small varicoceles may be appreciated as a distinct impulse and palpable dilation of the internal spermatic veins during the Valsalva maneuver. The best method to elicit a strong and sustained Valsalva is to tell the patient to bear down as if having a bowel movement. If a varicocele is detected, the patient should be placed supine. A varicocele should completely collapse when the patient is supine. A large varicocele, which does not collapse in the supine position, leads to suspicion of a retroperitoneal mass and an abdominal sonogram is indicated. In the hands of an experienced sonographer scrotal ultrasound with color flow Doppler is useful in the evaluation of questionable varicoceles, especially in obese men or men with a small tight scrotum. Our monographic criteria for the diagnosis of a varicocele is the presence of any internal spermatic veins greater than 3 mm in diameter associated with retrograde flow on Valsalva. Subclinical or questionable varicoceles are of limited clinical interest. Our data has clearly shown that response to varicocelectomy is related to varicocele size. Men with large varicoceles sustain a greater improvement in semen quality following varicocele surgery than men with small or subclinical varicoceles. Digital rectal examination is always performed. The size and consistency of the prostate is noted. Masses, cysts, irregularities, tenderness, and whether or not the seminal vesicles are palpable are noted. Stool should be tested for occult blood.

Center for Male Reproductive Medicine & Microsurgery Weill Cornell Medicine
525 E 68th Street
New York, NY 10065